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KMID : 0378019940370100113
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New Medical Journal
1994 Volume.37 No. 10 p.113 ~ p.119
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Ultrastructural Studies of Kidney in Dimethylnitrosamin and D-galactosamine Induced Rat Liver Injury
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Abstract
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It has been well known that renal functions are disturbed in patients with prologed hepatobiliary disease but its pathogenesis is not yet defined.
In order to disclose its pathogenesis, experimental hepatic injury was induced by intraperitoneal administration of Dimethylnitrosamin or D-galactosamine to rat On ultrastructural study, it were observed renal glomeruli of the rats.
The results obtained were as follows ;
1. In the Dimethylnitrosamine-treated rats, there were necrotic spces debris of necrotic hepatocytes and sinusoidal lining cells in the centrilobular areas, 5 days after administration.
2. In the D-galactosamine-treated rats, spotty necrosis with inflammatory cell infiltration throughout the lobule, swelling and increasing of Kupper cells were appeared 2 days after administration.
3. There were slightly thickening of renal glomerular basement membrane and sidening of the mesangeal matrix in Dimethylnitrosamine-treated rats, 14 days after administration, but no pathological changes were observed in glomerular basement membrane and mesangeal matrix in D-galactosamine-treated rats.
4. On the ultrastructural study of liver, degenerative change was most prominent 7 and 14´ days after administation of Dimethylnitrosamine and D-galactosamine, respectively.
5. On the ultrastructural study of the kidney, most prominent change was noted at 7 days after administration of Dimethylnitrosamine or D-galactosamine. from the above findings of electron microscopy, this study revealed that deposited on renal glomerular mesangium of the rats as a result of experimental hpatic injury induced by Dimethylnitrosamine and D-galactosamin.
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